{"product_id":"cyclin-d3-polyclonal-antibody-e-ab-90255","title":"Cyclin D3 Polyclonal Antibody - E-AB-90255","description":"\u003cp\u003eCyclin D3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90255-60, E-AB-90255-120, E-AB-90255-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cyclin D3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CCND3; cyclin D3; Cyclin D3\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P30281\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1\/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Cyclin D3\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 9kDa\/22kDa\/24kDa\/32kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 33kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146541170867,"sku":"E-AB-90255-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146541203635,"sku":"E-AB-90255-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146541236403,"sku":"E-AB-90255-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_1de45c2c-f21a-4cb0-848e-04662a661aac.png?v=1710297108","url":"https:\/\/afsbio.com\/products\/cyclin-d3-polyclonal-antibody-e-ab-90255","provider":"AFSBio Inc.","version":"1.0","type":"link"}