{"product_id":"cyclin-d3-rabbit-polyclonal-antibody-es7915","title":"Cyclin D3 Rabbit Polyclonal Antibody - ES7915","description":"\u003cp\u003eCyclin D3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7915-50, ES7915-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1\/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CCND3, G1\/S-specific cyclin-D3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Cyclin D3. AA range:243-292\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Cyclin D3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cyclin D3 Polyclonal Antibody detects endogenous levels of Cyclin D3 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Lung, Placenta, Synovial membrane tissue, Umbilical cord blood,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 32kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Cell cycle, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Wnt signaling pathway, Hippo signaling pathway, Focal adhesion, JAK-STAT signaling pathway, Measles, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Viral carcinogenesis, Chemical carcinogenesis - receptor activation\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Essential for the control of the cell cycle at the G1\/S (start) transition. Potentiates the transcriptional activity of ATF5\u003cbr\u003e\nSimilarity: Belongs to the cyclin family\u003cbr\u003e\nSimilarity: Belongs to the cyclin family. Cyclin D subfamily\u003cbr\u003e\nSubunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine\/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with ATF5. Interacts with EIF3K\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CCND3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: G1\/S-specific cyclin-D3\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12445\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P30282\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 25193\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P48961\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313772712115,"sku":"ES7915-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313772744883,"sku":"ES7915-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/cyclin-d3-rabbit-polyclonal-antibody-es7915","provider":"AFSBio Inc.","version":"1.0","type":"link"}