{"product_id":"cyfip2-polyclonal-antibody-ra23953","title":"CYFIP2 Polyclonal Antibody - RA23953","description":"\u003cp\u003eCYFIP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23953-50, RA23953-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level) .,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10\/HSPC300, NCKAP1 and WASF1\/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 26999\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 150+45\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96F07\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121227587763,"sku":"RA23953-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121227620531,"sku":"RA23953-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_003cd897-fd24-49d8-8b08-395e68e14cf7.png?v=1773345453","url":"https:\/\/afsbio.com\/products\/cyfip2-polyclonal-antibody-ra23953","provider":"AFSBio Inc.","version":"1.0","type":"link"}