{"product_id":"cyfip2-rabbit-pab-es8500","title":"CYFIP2 rabbit pAb - ES8500","description":"\u003cp\u003eCYFIP2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8500-50, ES8500-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level)., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10\/HSPC300, NCKAP1 and WASF1\/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, ELISA 1:10000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 150+45kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 26999\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q96F07\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202382651571,"sku":"ES8500-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202382684339,"sku":"ES8500-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_376ffd29-e346-410d-bd8f-8811e5e80948.png?v=1767127951","url":"https:\/\/afsbio.com\/products\/cyfip2-rabbit-pab-es8500","provider":"AFSBio Inc.","version":"1.0","type":"link"}