{"product_id":"cyp2r1-polyclonal-antibody-bs65875","title":"CYP2R1 Polyclonal Antibody-BS65875","description":"\u003cp\u003eCYP2R1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65875-50, BS65875-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q6VVX0\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eCYP2R1 Polyclonal Antibody-BS65875\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -48°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CYP2R1 Polyclonal Antibody detects endogenous levels of CYP2R1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~53kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Primary: Anti-CYP2R1 at 1\/1000 dilution, Primary: Anti- CYP2R1 at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human CYP2R1:251-350\/501\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962776228019,"sku":"BS65875-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962776260787,"sku":"BS65875-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_44092b4f-ba6f-4822-955f-a4d51ab616e2.jpg?v=1705318890","url":"https:\/\/afsbio.com\/products\/cyp2r1-polyclonal-antibody-bs65875","provider":"AFSBio Inc.","version":"1.0","type":"link"}