{"product_id":"cyp4f2-m66-polyclonal-antibody-bs9135","title":"CYP4F2 (M66) Polyclonal Antibody-BS9135","description":"\u003cp\u003eCYP4F2 (M66) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS9135-50, BS9135-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P78329\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eBackground: CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins. CYP4F2 catalyzes ω-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4, as well as arachidonic acid. CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid. X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). CYP4F2 participates in the ω-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CYP4F2 (M66) polyclonal antibody detects endogenous levels of CYP4F2 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CYP4F2 polyclonal antibody at 1:1000 dilution  Lane 1: HEPG2 whole cell lysate (55ug) \u003cbr\u003e\nLane 2: LO2 whole cell lysate (38ug)   Lane 3: The liver tissue lysate of Rat (41ug)  Lane 4: The liver tissue lysate of Mouse (38ug) , Immunohistochemistry (IHC) analyzes of CYP4F2 (M66) pAb in paraffin-embedded human liver cancer tissue.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cyp4f14; CYPIVF1; Cytochrome P450 LTB omega; Cytochrome P450; family 4; subfamily F; polypeptide 2; EC 1.14.14.1; Leukotriene b (4) 20 monooxygenase; Leukotriene b (4) omega hydroxylase; MGC126966; MGC93476; P450 A3;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 36-90 of Human CYP4F2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953247457459,"sku":"BS9135-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953247490227,"sku":"BS9135-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_851c5028-aeb4-4521-97ba-20b097e665d1.jpg?v=1705057627","url":"https:\/\/afsbio.com\/products\/cyp4f2-m66-polyclonal-antibody-bs9135","provider":"AFSBio Inc.","version":"1.0","type":"link"}