{"product_id":"cystatin-c-f122-polyclonal-antibody-bs3973","title":"Cystatin C (F122) Polyclonal Antibody-BS3973","description":"\u003cp\u003eCystatin C (F122) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3973-50, BS3973-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cystatin-C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin; CST3\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P01034\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cystatin C is a cysteine (thiol) protease inhibitor that belongs to the type II cystatin gene superfamily and is the most abundant extracellular inhibitor of cysteine proteases. Cystatin C is a constitutively secreted, amyloidogenic protein, which forms a two-fold symmetric dimer and modulates both cysteine protease activity and the expression of class II MHC molecules. Expression of cystatin C is an indicator of kidney function and glomerular filtration rate. Mutations in the cystatin C gene can lead to protein aggregates, which are implicated in hereditary amyloid angiopathy (HCCAA) and cerebral hemorrhage. Although both wild-type and mutant cystatin C are capable of forming concentration dependent inactive dimers, mutant cystatin C dimerizes at lower concentrations and is more susceptible to serine proteases, which may facilitate aggregation. In neuronal cells, oxidative stress stimulates expression of cystatin C, which may positively regulate apoptosis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cystatin C (F122) polyclonal antibody detects endogenous levels of Cystatin C protein =\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 16 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Cystatin C (F122) pAb at 1:1000 dilution\u003cbr\u003e\nLane 1: PC3 whole cell lysate(20ug)\u003cbr\u003e\nLane 2: The Brain tissue lysate of Mouse(40ug)\u003cbr\u003e\nLane 3: C6 whole cell lysate(40ug)\u003cbr\u003e\nLane 4: HepG2 whole cell lysate(40ug)\u003cbr\u003e\nLane 5: H1792 whole cell lysate(40ug)\u003cbr\u003e\nLane 6: HEK293T whole cell lysate(40ug)\u003cbr\u003e\nLane 7: MCF-7 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 101-150 of Human Cystatin C.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911807865011,"sku":"BS3973-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911807897779,"sku":"BS3973-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f16fd346-b449-47b8-8f92-33b2b15f58d4.jpg?v=1703179664","url":"https:\/\/afsbio.com\/products\/cystatin-c-f122-polyclonal-antibody-bs3973","provider":"AFSBio Inc.","version":"1.0","type":"link"}