{"product_id":"cytokeratin-1-polyclonal-antibody-bs90373","title":"Cytokeratin 1 Polyclonal Antibody-BS90373","description":"\u003cp\u003eCytokeratin 1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90373-50, BS90373-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P04264(Human) P04104(Mouse) Q6IMF3(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nIHC:1:100-1:500\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cytokeratin 1 polyclonal antibody detects endogenous levels of Cytokeratin 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 72 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Cytokeratin 1 on different lysates using anti-Cytokeratin 1 antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control: \u003cbr\u003e\n Lane 1: 293T \u003cbr\u003e\n Lane 2: Hela, Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-Cytokeratin 1 antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CK-1, K1, KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin-1, Cytokeratin1, EHK, EHK1, Epidermolytic hyperkeratosis 1, EPPK, Hair alpha protein, K1, K2C1, Keratin, Keratin type II cytoskeletal 1, Keratin-1, Keratin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keratin Kb1, Type-II keratin Kb1,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42979804283059,"sku":"BS90373-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42979804315827,"sku":"BS90373-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b50cc423-831e-4eeb-b14a-3a541a9b456b.jpg?v=1705752928","url":"https:\/\/afsbio.com\/products\/cytokeratin-1-polyclonal-antibody-bs90373","provider":"AFSBio Inc.","version":"1.0","type":"link"}