{"product_id":"cytokeratin-8-acetyl-lys483-polyclonal-antibody-bt-ap02476","title":"Cytokeratin 8 (Acetyl Lys483) Polyclonal Antibody - BT-AP02476","description":"\u003cp\u003eCytokeratin 8 (Acetyl Lys483) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02476-20, BT-AP02476-50, BT-AP02476-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of KRT8 typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. Keratin 8 plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in KRT8 cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for KRT8.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: KRT8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Cytokeratin 8 (Acetyl Lys483) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 53573\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P05787; Mouse: P11679\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: KRT8; CYK8; Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 3856\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240254202035,"sku":"BT-AP02476-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240254234803,"sku":"BT-AP02476-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240254267571,"sku":"BT-AP02476-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e07f65d9-625c-415f-97a5-c57166e86cff.png?v=1769405776","url":"https:\/\/afsbio.com\/products\/cytokeratin-8-acetyl-lys483-polyclonal-antibody-bt-ap02476","provider":"AFSBio Inc.","version":"1.0","type":"link"}