{"product_id":"dctn1-polyclonal-antibody-e-ab-60443","title":"DCTN1 Polyclonal Antibody - E-AB-60443","description":"\u003cp\u003eDCTN1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60443-60, E-AB-60443-120, E-AB-60443-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: DCTN1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DCTN1; DAP-150; DP-150; P135\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology,Neuroscience,Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q14203\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human DCTN1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 126kDa\/127kDa\/136kDa\/138kDa\/140kDa\/141kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 150kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146065674419,"sku":"E-AB-60443-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146065707187,"sku":"E-AB-60443-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146065739955,"sku":"E-AB-60443-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5f54e9e4-3c8e-48fc-a434-bccd8ca0b242.png?v=1710290690","url":"https:\/\/afsbio.com\/products\/dctn1-polyclonal-antibody-e-ab-60443","provider":"AFSBio Inc.","version":"1.0","type":"link"}