{"product_id":"ddb1-mouse-monoclonal-antibody-ra11085","title":"DDB1 Mouse Monoclonal Antibody - RA11085","description":"\u003cp\u003eDDB1 Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA11085-50, RA11085-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: damage specific DNA binding protein 1 (DDB1) Homo sapiens The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecul\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat; Monkey\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 1642\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 127\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q16531\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119028134067,"sku":"RA11085-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119028166835,"sku":"RA11085-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_31162051-2045-42cc-8ee1-dd6d5a5236f1.png?v=1773344416","url":"https:\/\/afsbio.com\/products\/ddb1-mouse-monoclonal-antibody-ra11085","provider":"AFSBio Inc.","version":"1.0","type":"link"}