{"product_id":"ddx58-rabbit-polyclonal-antibody-es11056","title":"DDX58 Rabbit Polyclonal Antibody - ES11056","description":"\u003cp\u003eDDX58 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11056-50, ES11056-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: DDX58,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: DDX58 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Present in vascular smooth cells (at protein level).\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 101kD\u003c\/p\u003e\n\n\u003cp\u003eFields: NF-kappa B signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Hepatitis B, Measles, Influenza A, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The 2 CARD domains are responsible for interaction with and signaling through MAVS. Domain: The helicase domain is responsible for dsRNA recognition. Domain: The repressor domain controls homomultimerization and interaction with MAVS. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS\/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. induction:By bacterial lipopolysaccharide (LPS) in endothelial cells. By IFN-alpha, -beta and -gamma. PTM: Isgylated. Conjugated to ubiquitin-like protein ISG15\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cell junction, tight junction. Colocalized with TRIM25 at cytoplasmic perinuclear bodies. Associated with the actin cytoskeleton at membrane ruffles.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: DDX58\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Probable ATP-dependent RNA helicase DDX58, EC 3.6.4.13, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 23586\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: O95786\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q6Q899\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825496940723,"sku":"ES11056-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825496973491,"sku":"ES11056-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/ddx58-rabbit-polyclonal-antibody-es11056","provider":"AFSBio Inc.","version":"1.0","type":"link"}