{"product_id":"defb4-polyclonal-antibody-bs7188","title":"DEFB4 Polyclonal Antibody-BS7188","description":"\u003cp\u003eDEFB4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7188-50, BS7188-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O15263\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eDEFB4 Polyclonal Antibody-BS7188\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: β-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, β-defensins are developmentally regulated. Unlike the other previously described human β-defensins, human β-defensin 4 (hBD-4) expression is restricted to a few tissues, with highest expression in testis. A restricted pattern is also exhibited by mouse β-defensin 4. Rat β-defensin 4 (also desiganated BD-4, RBD-4, BD-2, and RBD-2) is developmentally regulated in the lung and is predominantly expressed in the lung and, to a lesser extent, in the trachea and tongue. It exhibits a regulation pattern similar to that of specific genes involved in host defense around the time of birth. The selectivity in both expression pattern and antimicrobial activity of human β-defensin 4 suggests that it is best suited to act at the epithelial locations where it is expressed.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: DEFB4 polyclonal antibody detects endogenous levels of DEFB4 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 8 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry of paraffin-embedded rat lung using DEFB4A antibody at dilution of 1:100 (40x lens) ., Immunohistochemistry of paraffin-embedded mouse lung using DEFB4A antibody at dilution of 1:100 (40x lens) .\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Beta-defensin 4A; Beta-defensin 2; BD-2; hBD-2; Defensin beta 2; Skin-antimicrobial peptide 1; SAP1; DEFB4A; DEFB102, DEFB2, DEFB4; DEFB4B; β-defensin 4A; Defensin-β2; Defensin β2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human DEFB4.\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962814140595,"sku":"BS7188-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962814173363,"sku":"BS7188-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e33e670e-3a9e-4ec0-8095-0688325c1be3.jpg?v=1705319092","url":"https:\/\/afsbio.com\/products\/defb4-polyclonal-antibody-bs7188","provider":"AFSBio Inc.","version":"1.0","type":"link"}