{"product_id":"den1b-rabbit-polyclonal-antibody-es16970","title":"DEN1B Rabbit Polyclonal Antibody - ES16970","description":"\u003cp\u003eDEN1B Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16970-50, ES16970-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2, see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human DEN1B AA range: 325-375\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: DEN1B\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of DEN1B at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary, Significantly up-regulated in effector memory T-cells as compared with naive T-cells,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 47kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: PTM: Isoform 5 is phosphorylated on Tyr-475 and Tyr-484\u003cbr\u003e\nSimilarity: Contains 1 dDENN domain\u003cbr\u003e\nSimilarity: Contains 1 DENN domain\u003cbr\u003e\nSimilarity: Contains 1 uDENN domain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm, cytosol Cytoplasmic vesicle, clathrin-coated vesicle\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: DENND1B C1orf218 FAM31B\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: DEN1B\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 329260\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q3U1T9\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315513577651,"sku":"ES16970-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315513610419,"sku":"ES16970-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/den1b-rabbit-polyclonal-antibody-es16970","provider":"AFSBio Inc.","version":"1.0","type":"link"}