{"product_id":"derl1-polyclonal-antibody-bt-ap08449","title":"DERL1 Polyclonal Antibody - BT-AP08449","description":"\u003cp\u003eDERL1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08449-20, BT-AP08449-50, BT-AP08449-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimerandapos;s disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: DERL1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Derlin-1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9BUN8; Mouse: Q99J56\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Derlin-1;Degradation in endoplasmic reticulum protein 1;DERtrin-1;Der1-like protein 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 79139\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239116562611,"sku":"BT-AP08449-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239116595379,"sku":"BT-AP08449-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239116628147,"sku":"BT-AP08449-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_bf743af6-f720-4b2d-b133-8e818e042ca5.png?v=1769389335","url":"https:\/\/afsbio.com\/products\/derl1-polyclonal-antibody-bt-ap08449","provider":"AFSBio Inc.","version":"1.0","type":"link"}