{"product_id":"dhrs4-polyclonal-antibody-ra24211","title":"DHRS4 Polyclonal Antibody - RA24211","description":"\u003cp\u003eDHRS4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA24211-50, RA24211-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:R-CHOH-R' + NADP (+) = R-CO-R' + NADPH.,function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.,miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid.,similarity:Belongs to the short-chain dehydrogenases\/reductases (SDR) family.,subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not.,subunit:Homotetramer.,tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level) . Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level) . Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: DHRS4; Dehydrogenase\/reductase SDR family member 4; NADPH-dependent carbonyl reductase\/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase\/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 10901\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 32-34\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9BTZ2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121242103987,"sku":"RA24211-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121242136755,"sku":"RA24211-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5d8a5d23-0267-4bfd-b18b-dfcdd8446456.png?v=1773345620","url":"https:\/\/afsbio.com\/products\/dhrs4-polyclonal-antibody-ra24211","provider":"AFSBio Inc.","version":"1.0","type":"link"}