{"product_id":"dhx58-polyclonal-antibody-bt-ap15235","title":"DHX58 Polyclonal Antibody - BT-AP15235","description":"\u003cp\u003eDHX58 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15235-20, BT-AP15235-50, BT-AP15235-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Negative regulator of host innate immune defense against viruses. The repressor domain of DHX58 interacts with DDX58 and negatively regulates DDX58-mediated signaling. Binds dsRNA produced during viral replication, in particuliar HCV RNA.,Belongs to the helicase family.,Contains 1 helicase ATP-binding domain.,Contains 1 helicase C-terminal domain.,subunit:Interacts with DDX58 and probably blocks its homomultimerization.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DHX58\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Probable ATP-dependent RNA helicase DHX58\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q96C10; Mouse: Q99J87\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Probable ATP-dependent RNA helicase DHX58;EC 3.6.4.13;Probable ATP-dependent helicase LGP2;Protein D11Lgp2 homolog;RIG-I-like receptor 3;RLR-3;RIG-I-like receptor LGP2;RLR\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 79132\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239118954675,"sku":"BT-AP15235-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239118987443,"sku":"BT-AP15235-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239119020211,"sku":"BT-AP15235-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7eb11b56-5c00-4c47-bdf6-258c8e37ee43.png?v=1769389359","url":"https:\/\/afsbio.com\/products\/dhx58-polyclonal-antibody-bt-ap15235","provider":"AFSBio Inc.","version":"1.0","type":"link"}