{"product_id":"dio3-polyclonal-antibody-ra24216","title":"DIO3 Polyclonal Antibody - RA24216","description":"DIO3 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA24216-50, RA24216-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: deiodinase, iodothyronine type III (DIO3) Homo sapiens The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in pregnant uterus, placenta, fetal and neonatal tissues, and thought to prevent premature exposure of developing fetal tissues to adult levels of thyroid hormones. It regulates circulating fetal thyroid hormone concentrations, and thus plays a critical role in mammalian development. Knockout mice lacking this gene exhibit abnormalities related to development and reproduction, and increased activity of this enzyme in infants with hemangiomas causes severe hypothyroidism. This protei\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: DIO3; ITDI3; TXDI3; Type III iodothyronine deiodinase; 5DIII; DIOIII; Type 3 DI; Type-III 5'-deiodinase\n\nApplications: WB; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 1735\n\nProtein MW (KDa): 31\n\nSWISS: P55073\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121242398899,"sku":"RA24216-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121242431667,"sku":"RA24216-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d78cc7ee-0a1b-4071-818e-10d4af503939.png?v=1773345624","url":"https:\/\/afsbio.com\/products\/dio3-polyclonal-antibody-ra24216","provider":"AFSBio Inc.","version":"1.0","type":"link"}