{"product_id":"dmp1-polyclonal-antibody-bs7995","title":"DMP1 Polyclonal Antibody-BS7995","description":"\u003cp\u003eDMP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS7995-50, BS7995-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13316\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: DMP-1 (dentin matrix protein-1), also known as dentin matrix acidic phosphoprotein-1, is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: DMP1 polyclonal antibody detects endogenous levels of DMP1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 68 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of DMP1 polyclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ARHP; \u003cbr\u003e\nARHR; \u003cbr\u003e\nAV020965; \u003cbr\u003e\nDentin matrix acidic phosphoprotein 1; \u003cbr\u003e\nDentin matrix protein 1; \u003cbr\u003e\nDENTMAT; \u003cbr\u003e\nDMP 1; \u003cbr\u003e\nDmp; \u003cbr\u003e\nMGC130441; \u003cbr\u003e\nPP; \u003cbr\u003e\nSerine rich acidic phosphoprotein;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant full length Human DMP1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923470323891,"sku":"BS7995-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923470356659,"sku":"BS7995-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_af11cd06-8a7f-41ea-b1b9-5fe0fe8be228.jpg?v=1703850068","url":"https:\/\/afsbio.com\/products\/dmp1-polyclonal-antibody-bs7995","provider":"AFSBio Inc.","version":"1.0","type":"link"}