{"product_id":"dnajb14-polyclonal-antibody-e-ab-63811","title":"DNAJB14 Polyclonal Antibody - E-AB-63811","description":"\u003cp\u003eDNAJB14 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-63811-60, E-AB-63811-120, E-AB-63811-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: DNAJB14\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DNAJB14; EGNR9427; PRO34683\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q8TBM8\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acts as a co-chaperone with HSPA8\/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD pathway. Acts by determining HSPA8\/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8\/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8\/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8\/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8\/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human DNAJB14\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:4000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33kDa\/42kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 42kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148649463987,"sku":"E-AB-63811-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148649496755,"sku":"E-AB-63811-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148649529523,"sku":"E-AB-63811-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c783634e-9db3-4e5c-9bee-7b062475b3ca.png?v=1710327311","url":"https:\/\/afsbio.com\/products\/dnajb14-polyclonal-antibody-e-ab-63811","provider":"AFSBio Inc.","version":"1.0","type":"link"}