{"product_id":"dnaseⅰpolyclonal-antibody-e-ab-40592","title":"DnaseⅠPolyclonal Antibody - E-AB-40592","description":"\u003cp\u003eDnaseⅠPolyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-40592-50, E-AB-40592-100, E-AB-40592-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: DnaseⅠ\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Deoxyribonuclease-1; DNASE1; DNL1; DRNI\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P24855\u003c\/p\u003e\n\n\u003cp\u003eBackground: Deoxyribonuclease I (DNase I) is an endonuclease which is secreted to cleave DNA in the extracellular space down to an average of tetranucleotides with 5′ monophosphate and 3′ hydroxyl DNA ends . Both single-stranded DNA and double-stranded DNA are degraded by Dnase I. This nuclease appears to account for the major nucleolytic activity on DNA in serum and is responsible for the degradation of the majority of circulating DNA derived from apoptotic and necrotic cell death and from neutrophil extracellular traps. In addition to its role in the serum, it has been proposed as one of the deoxyribonucleases responsible for DNA fragmentation in the process of apoptosis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.7mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Human DnaseⅠ protein expressed by E.coli.\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen Affinity Purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 31kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 31kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μL","offer_id":43146036576435,"sku":"E-AB-40592-50","price":175.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":43146036609203,"sku":"E-AB-40592-100","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146036641971,"sku":"E-AB-40592-200","price":532.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c720951c-4668-43a1-ac8b-7aae5cb8be9d.png?v=1710290296","url":"https:\/\/afsbio.com\/products\/dnase%e2%85%b0polyclonal-antibody-e-ab-40592","provider":"AFSBio Inc.","version":"1.0","type":"link"}