{"product_id":"dnmt1-polyclonal-antibody-bt-ap08573","title":"DNMT1 Polyclonal Antibody - BT-AP08573","description":"\u003cp\u003eDNMT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08573-20, BT-AP08573-50, BT-AP08573-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DNMT1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: DNA\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P26358; Mouse: P13864; Rat: Q9Z330\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DNA;cytosine-5-methyltransferase 1;Dnmt1;EC 2.1.1.37;CXXC-type zinc finger protein 9;DNA methyltransferase HsaI;DNA MTase HsaI;M.HsaI;MCMT\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1786\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239122591923,"sku":"BT-AP08573-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239122624691,"sku":"BT-AP08573-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239122657459,"sku":"BT-AP08573-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5f2971de-ef53-49ef-8d68-617a210a5494.png?v=1769389419","url":"https:\/\/afsbio.com\/products\/dnmt1-polyclonal-antibody-bt-ap08573","provider":"AFSBio Inc.","version":"1.0","type":"link"}