{"product_id":"dok-3-polyclonal-antibody-bt-ap02699","title":"Dok-3 Polyclonal Antibody - BT-AP02699","description":"\u003cp\u003eDok-3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02699-20, BT-AP02699-50, BT-AP02699-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dok-1, Dok-2 and Dok-3 are members of a class of \"docking\" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DOK3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Dok-3 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 53288\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q7L591; Mouse: Q9QZK7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DOK3; Docking protein 3; Downstream of tyrosine kinase 3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 79930; Mouse: 27261\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240268128435,"sku":"BT-AP02699-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240268161203,"sku":"BT-AP02699-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240268193971,"sku":"BT-AP02699-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_49021fc4-bb7c-4e24-9ade-38575385dce2.png?v=1769405981","url":"https:\/\/afsbio.com\/products\/dok-3-polyclonal-antibody-bt-ap02699","provider":"AFSBio Inc.","version":"1.0","type":"link"}