{"product_id":"dok-6-polyclonal-antibody-bt-ap02702","title":"Dok-6 Polyclonal Antibody - BT-AP02702","description":"\u003cp\u003eDok-6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP02702-20, BT-AP02702-50, BT-AP02702-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The downstream of kinase family (Dok-1-7) are members of a class of \"docking\" proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DOK6\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Dok-6 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 38318\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q6PKX4; Mouse: Q2MHE5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: DOK6; DOK5L; Docking protein 6; Downstream of tyrosine kinase 6\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 220164; Mouse: 623279\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240268423347,"sku":"BT-AP02702-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240268456115,"sku":"BT-AP02702-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240268488883,"sku":"BT-AP02702-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_711ce1ef-f40c-4dbb-b808-89d36013072b.png?v=1769405985","url":"https:\/\/afsbio.com\/products\/dok-6-polyclonal-antibody-bt-ap02702","provider":"AFSBio Inc.","version":"1.0","type":"link"}