{"product_id":"doublecortin-phospho-ser297-rabbit-pab-es16912","title":"Doublecortin (phospho-Ser297) rabbit pAb - ES16912","description":"\u003cp\u003eDoublecortin (phospho-Ser297) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16912-50, ES16912-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia (\"double cortex\" syndrome) in females and lissencephaly (\"smooth brain\u0026amp;quo\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized phosho peptide around human Doublecortin (Ser297)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 44kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 1641\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O43602\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cell projection, neuron projection. Localizes at neurite tips.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202419876019,"sku":"ES16912-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202419908787,"sku":"ES16912-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_c51c12e4-93d5-4f3c-86cf-a896d0070ce7.png?v=1767128790","url":"https:\/\/afsbio.com\/products\/doublecortin-phospho-ser297-rabbit-pab-es16912","provider":"AFSBio Inc.","version":"1.0","type":"link"}