{"product_id":"dreb-rabbit-polyclonal-antibody-es16896","title":"DREB Rabbit Polyclonal Antibody - ES16896","description":"\u003cp\u003eDREB Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16896-50, ES16896-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human DREB AA range: 484-534\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: DREB\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of DREB at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in the brain, with expression in the molecular layer of the dentate gyrus, stratum pyramidale, and stratum radiatum of the hippocampus (at protein level) (PubMed:8838578), Also expressed in the terminal varicosities distributed along dendritic trees of pyramidal cells in CA4 and CA3 of the hippocampus (at protein level) (PubMed:8838578), Expressed in pyramidal cells in CA2, CA1 and the subiculum of the hippocampus (at protein level) (PubMed:8838578), Expressed in peripheral blood lymphocytes, including T-cells (at protein level) (PubMed:20215400), Expressed in the brain (PubMed:8216329, Ref,2), Expressed in the heart, placenta, lung, skeletal muscle, kidney, pancreas, skin fibroblasts, gingival fibroblasts and bone-derived cells (Ref,2),\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 71kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively\u003cbr\u003e\nSimilarity: Contains 1 ADF-H domain\u003cbr\u003e\nSubunit: Binds F-actin\u003cbr\u003e\nTissue Specificity: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cell projection, dendrite Cytoplasm, cell cortex Cell junction Cell projection, growth cone In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm (PubMed:20215400) In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400) Colocalized with RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: DBN1 D0S117E\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: DREB\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 56320\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9QXS6\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 81653\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q07266\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315492540595,"sku":"ES16896-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315492573363,"sku":"ES16896-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/dreb-rabbit-polyclonal-antibody-es16896","provider":"AFSBio Inc.","version":"1.0","type":"link"}