{"product_id":"dtl-polyclonal-antibody-bt-ap15331","title":"DTL Polyclonal Antibody - BT-AP15331","description":"\u003cp\u003eDTL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15331-20, BT-AP15331-50, BT-AP15331-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: developmental stage:Expressed in all fetal tissues examined, included brain, lung, liver, and kidney.,Required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. Seems to be necessary to ensure proper cell cycle regulation of DNA replication. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. May play a role in cell proliferation of NT2 embryonal carcinoma cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the WD repeat cdt2 family.,Contains 7 WD repeats.,subcellular location:Nuclear matrix-associated protein. Translocates from the interphase nucleus to the metaphase cytoplasm during mitosis.,subunit:Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1.,tissue specificity:Expressed in placenta and testis, very low expression seen in skeletal muscle. Detected in all hematopoietic tissues examined, with highest expression in thymus and bone marrow. A low level detected in the spleen and lymph node, and barely detectable level in the peripheral leukocytes. RA treatment down-regulated the expression in NT2 cell.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer; Cell biology; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DTL\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Denticleless protein homolog\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NZJ0; Mouse: Q3TLR7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Denticleless protein homolog;DDB1- and CUL4-associated factor 2;Lethal;2 denticleless protein homolog;Retinoic acid-regulated nuclear matrix-associated protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 51514\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239124918451,"sku":"BT-AP15331-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239124951219,"sku":"BT-AP15331-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239124983987,"sku":"BT-AP15331-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d3a48c76-ca61-4c7b-9d99-dbd6bb2ea3c5.png?v=1769389458","url":"https:\/\/afsbio.com\/products\/dtl-polyclonal-antibody-bt-ap15331","provider":"AFSBio Inc.","version":"1.0","type":"link"}