{"product_id":"dtx3-rabbit-polyclonal-antibody-es16883","title":"DTX3 Rabbit Polyclonal Antibody - ES16883","description":"\u003cp\u003eDTX3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16883-50, ES16883-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human DTX3 AA range: 87-137\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: DTX3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of DTX3 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 38kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Notch signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity\u003cbr\u003e\nSequence Caution: Intron retention\u003cbr\u003e\nSimilarity: Belongs to the Deltex family\u003cbr\u003e\nSimilarity: Contains 1 RING-type zinc finger\u003cbr\u003e\nSubunit: Homomultimer. May form a heteromultimer with other members of the Deltex family. Interacts with NOTCH1\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: DTX3 RNF154\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: DTX3\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 80904\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q80V91\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315488182451,"sku":"ES16883-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315488215219,"sku":"ES16883-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/dtx3-rabbit-polyclonal-antibody-es16883","provider":"AFSBio Inc.","version":"1.0","type":"link"}