{"product_id":"dusp10-polyclonal-antibody-bs65743","title":"DUSP10 Polyclonal Antibody-BS65743","description":"\u003cp\u003eDUSP10 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65743-50, BS65743-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9Y6W6\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eDUSP10 Polyclonal Antibody-BS65743\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC-P=1:100-500\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and\/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK\/ERK, SAPK\/JNK and p38. MKP-5 preferentially binds to p38, but also to SAPK\/JNK. It is ubiquitously expressed and localizes to both the cytoplasm and the nucleus. MKP-5 has been implicated in cell proliferation and apoptosis, tumor invasion and immune responses.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: DUSP10 Polyclonal Antibody detects endogenous levels of DUSP10 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 53kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Paraformaldehyde-fixed, paraffin embedded (Mouse brain)Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DUSP10) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C, Paraformaldehyde-fixed, paraffin embedded (Human breast carcinoma)Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (DUSP10) Polyclonal Antibody, Unconjugated at 1:400 overnight at 4°C\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: MKP5; MKP 5; MKP-5; Dual specificity phosphatase 10; Dual specificity phosphatase MKP 5; Dual specificity phosphatase MKP5; Dual specificity protein phosphatase 10; DUS10_HUMAN; DUSP 10; DUSP10; DUSP10 protein; MAP kinase phosphatase 5; Mitogen activated protein kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; Serine\/threonine specific protein phosphatase.聽聽\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from human DUSP10\/MKP5:161-260\/482\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962764431539,"sku":"BS65743-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962764464307,"sku":"BS65743-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_14dffe44-4ff9-4ca8-893a-43d9fcb3556f.jpg?v=1705318816","url":"https:\/\/afsbio.com\/products\/dusp10-polyclonal-antibody-bs65743","provider":"AFSBio Inc.","version":"1.0","type":"link"}