{"product_id":"dusp6-rabbit-polyclonal-antibody-es20772","title":"DUSP6 Rabbit Polyclonal Antibody - ES20772","description":"\u003cp\u003eDUSP6 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20772-50, ES20772-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine\/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK\/ERK, SAPK\/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in t\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: DUSP6, MKP3, PYST1, Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3, MAP kinase phosphatase 3, MKP-3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of DUSP6\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: DUSP6\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: DUSP6 Rabbit Polyclonal detects endogenous levels of DUSP6\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-3000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in keratinocytes (at protein level),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 42,44kD\u003c\/p\u003e\n\n\u003cp\u003eFields: MAPK signaling pathway, Transcriptional misregulation in cancer, Acute myeloid leukemia\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: A phosphoprotein + H(2)O = a protein + phosphate\u003cbr\u003e\nCatalytic Activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate\u003cbr\u003e\nFunction: Inactivates MAP kinases. Has a specificity for the ERK family\u003cbr\u003e\nSimilarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily\u003cbr\u003e\nSimilarity: Contains 1 rhodanese domain\u003cbr\u003e\nSimilarity: Contains 1 tyrosine-protein phosphatase domain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: DUSP6\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9DBB1\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q64346\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314187522227,"sku":"ES20772-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314187554995,"sku":"ES20772-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/dusp6-rabbit-polyclonal-antibody-es20772","provider":"AFSBio Inc.","version":"1.0","type":"link"}