{"product_id":"dyr1a-polyclonal-antibody-bt-ap15347","title":"DYR1A Polyclonal Antibody - BT-AP15347","description":"\u003cp\u003eDYR1A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15347-20, BT-AP15347-50, BT-AP15347-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine\/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5andapos; UTR or in the 3andapos; co\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Microbiology; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: DYRK1A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Dual specificity tyrosine-phosphorylation-regulated kinase 1A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13627; Mouse: Q61214; Rat: Q63470\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 1A;EC 2.7.12.1;Dual specificity YAK1-related kinase;HP86;Protein kinase minibrain homolog;MNBH;hMNB\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1859\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239125934259,"sku":"BT-AP15347-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239125967027,"sku":"BT-AP15347-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239125999795,"sku":"BT-AP15347-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_03c2fe3d-cc20-4aaf-ad55-45bad0e91486.png?v=1769389475","url":"https:\/\/afsbio.com\/products\/dyr1a-polyclonal-antibody-bt-ap15347","provider":"AFSBio Inc.","version":"1.0","type":"link"}