{"product_id":"e-cadherin-monoclonal-antibody-e-ab-70249","title":"E-Cadherin Monoclonal Antibody - E-AB-70249","description":"\u003cp\u003eE-Cadherin Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-70249-60, E-AB-70249-120, E-AB-70249-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: E-Cadherin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Arc 1; CADH1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120\/80; CD 324; CD324; CD324 antigen; cdh1; CDHE; E-Cad\/CTF3; E-cadherin; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental Biology, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: EC125D\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P09803,Q9R0T4\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and\/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.6 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to MouseE-cadherin\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:200-1:800\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135932367027,"sku":"E-AB-70249-60","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135932399795,"sku":"E-AB-70249-120","price":364.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135932432563,"sku":"E-AB-70249-200","price":574.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b46a8659-d00a-4a85-a5b2-b2beaefeeb5f.png?v=1709986705","url":"https:\/\/afsbio.com\/products\/e-cadherin-monoclonal-antibody-e-ab-70249","provider":"AFSBio Inc.","version":"1.0","type":"link"}