{"product_id":"e2a-monoclonal-antibody-bt-mca0454","title":"E2A Monoclonal Antibody - BT-MCA0454","description":"\u003cp\u003eE2A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA0454-50, BT-MCA0454-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1|19), with PBX1), childhood leukemia (t(19|19), with TFPT) and acute leukemia (t(12|19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TCF3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Transcription factor E2-alpha\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P15923; Mouse: P15806\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TCF3; BHLHB21; E2A; ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12; E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription facto\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6929\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238692610227,"sku":"BT-MCA0454-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238692642995,"sku":"BT-MCA0454-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_4ba5e463-2288-4d84-89b2-7249e0af7820.png?v=1769383835","url":"https:\/\/afsbio.com\/products\/e2a-monoclonal-antibody-bt-mca0454","provider":"AFSBio Inc.","version":"1.0","type":"link"}