{"product_id":"e2a-monoclonal-antibody-ra11110","title":"E2A Monoclonal Antibody - RA11110","description":"\u003cp\u003eE2A Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA11110-50, RA11110-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: transcription factor 3 (TCF3) Homo sapiens This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t (1;19), with PBX1), childhood leukemia (t (19;19), with TFPT) and acute leukemia (t (12;19), with ZNF384) . Alternatively spliced transcript variants encoding multiple isoforms have bee\u003c\/p\u003e\n\n\u003cp\u003eCondition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; FCM; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 6929\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P15923\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45118961385651,"sku":"RA11110-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45118961418419,"sku":"RA11110-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_948dbf52-444d-467a-ad5c-c90808b0d783.png?v=1773343726","url":"https:\/\/afsbio.com\/products\/e2a-monoclonal-antibody-ra11110","provider":"AFSBio Inc.","version":"1.0","type":"link"}