{"product_id":"e2f-1-acetyl-lys120-polyclonal-antibody-ra24384","title":"E2F-1 (Acetyl Lys120) Polyclonal Antibody - RA24384","description":"\u003cp\u003eE2F-1 (Acetyl Lys120) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA24384-50, RA24384-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: E2F transcription factor 1 (E2F1) Homo sapiens The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media\u003c\/p\u003e\n\n\u003cp\u003eCondition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB: 1:500-10000 ELISA: 1:10000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: E2F1 RBBP3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human:K120; Mouse:K115; Rat:K118\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 1869\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 70\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q01094\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121248985267,"sku":"RA24384-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121249018035,"sku":"RA24384-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_78bb00e7-92c1-41f8-a57c-aec7bec5246f.png?v=1773345702","url":"https:\/\/afsbio.com\/products\/e2f-1-acetyl-lys120-polyclonal-antibody-ra24384","provider":"AFSBio Inc.","version":"1.0","type":"link"}