{"product_id":"e2f7-rabbit-polyclonal-antibody-es10623","title":"E2F7 Rabbit Polyclonal Antibody - ES10623","description":"\u003cp\u003eE2F7 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10623-50, ES10623-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein . at AA range: 560-640\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: E2F7,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: E2F7 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 100kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer. Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession. Similarity: Belongs to the E2F\/DP family. Subunit: Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: E2F7\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Transcription factor E2F7, E2F-7\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 144455\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: Q96AV8\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q6S7F2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825495498931,"sku":"ES10623-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825495531699,"sku":"ES10623-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/e2f7-rabbit-polyclonal-antibody-es10623","provider":"AFSBio Inc.","version":"1.0","type":"link"}