{"product_id":"edaradd-polyclonal-antibody-e-ab-52310","title":"EDARADD Polyclonal Antibody - E-AB-52310","description":"\u003cp\u003eEDARADD Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52310-60, E-AB-52310-120, E-AB-52310-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: EDARADD\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cr; Crinkled homolog; ectodysplasia A receptor associated death domain; Ectodysplasin-A receptor-associated adapter protein; ED3; EDA3; EDAD; EDAR associated death domain; EDAR-associated death domain protein; EDARADD; Protein crinkled homolog\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling, Developmental biology, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q8WWZ3\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.9 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Full length fusion protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:35-1:200, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133460840627,"sku":"E-AB-52310-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133460873395,"sku":"E-AB-52310-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133460906163,"sku":"E-AB-52310-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a9c48dfa-36f1-4e39-8eb5-91801582b08e.png?v=1709899300","url":"https:\/\/afsbio.com\/products\/edaradd-polyclonal-antibody-e-ab-52310","provider":"AFSBio Inc.","version":"1.0","type":"link"}