{"product_id":"egf-receptor-e746-a750del-specific-rabbit-pab-a23256","title":"EGF Receptor (E746-A750del Specific) Rabbit pAb - A23256","description":"\u003cp\u003eEGF Receptor (E746-A750del Specific) Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A23256-20, A23256-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 134kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 175kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1956\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P00533\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Protein phosphorylation, Cancer, Tumor biomarkers, Signal Transduction, G protein signaling, Kinase, Tyrosine kinases, ErbB-HER Signaling Pathway, Cell Biology Developmental Biology, Growth factors, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Cardiovascular, Angiogenesis.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: EGFR\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189842206899,"sku":"A23256-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189842239667,"sku":"A23256-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ef2334cf-adc1-4aea-bd5e-c9a622263326.png?v=1766436552","url":"https:\/\/afsbio.com\/products\/egf-receptor-e746-a750del-specific-rabbit-pab-a23256","provider":"AFSBio Inc.","version":"1.0","type":"link"}