{"product_id":"eif2ak3-monoclonal-antibody-bt-mca3889","title":"EIF2AK3 Monoclonal Antibody - BT-MCA3889","description":"\u003cp\u003eEIF2AK3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3889-50, BT-MCA3889-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: EIF2AK3\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5G5\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: EIF2AK3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human EIF2AK3 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 125kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q9NZJ5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PEK, WRS, PERK, EIF2AK3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 9451\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238425878707,"sku":"BT-MCA3889-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238425911475,"sku":"BT-MCA3889-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f7255ea9-5268-4ba8-b836-cf00a32d52a0.png?v=1769380600","url":"https:\/\/afsbio.com\/products\/eif2ak3-monoclonal-antibody-bt-mca3889","provider":"AFSBio Inc.","version":"1.0","type":"link"}