{"product_id":"eif3c-polyclonal-antibody-e-ab-52777","title":"EIF3C Polyclonal Antibody - E-AB-52777","description":"\u003cp\u003eEIF3C Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52777-60, E-AB-52777-120, E-AB-52777-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: EIF3C\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Cell migration inducing protein 17; eIF 3c; eIF3 p110; eIF3-p110; eIF3c; EIF3C; EIF3CL; EIF3S8; EIF3S8 protein; Eukaryotic translation initiation factor 3 subunit 8 (110kD); Eukaryotic translation initiation factor 3 subunit 8 110kDa; Eukaryotic translation initiation factor 3 subunit 8; Eukaryotic translation initiation factor 3 subunit C\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q99613\u003c\/p\u003e\n\n\u003cp\u003eBackground: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.6 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human EIF3C\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:40-1:200, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133536501939,"sku":"E-AB-52777-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133536534707,"sku":"E-AB-52777-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133536567475,"sku":"E-AB-52777-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_55c1e534-0db7-4410-b8ed-ced7105c8502.png?v=1709899723","url":"https:\/\/afsbio.com\/products\/eif3c-polyclonal-antibody-e-ab-52777","provider":"AFSBio Inc.","version":"1.0","type":"link"}