Human Elastase - 1.0mg

Human Elastase - 1.0mg

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Human leukocyte elastase
HLE 
Elastase 2

Uniprot ID:  P08246
mRNA RefSeq:  NM_001972
Protein RefSeq:  NP_001963

Size: 1.0mg
Source: Human Neutrophils
Catalogue Number: ATE01-10

Product Information

Elastase, part of the serine protease superfamily, is a 30kDa protein expressed in neutrophil granules with a 267 amino acid residue. It undergoes posttranslational modification at both termini during processing of the enzyme. Reported to be present as a marker in IBD, it has also been implicated in congenital and cyclic neutropenia. Elastase reportedly could be used as a biomarker for the progression of cancer, specifically in colorectal cancer.

 

PDF-logo-dl Elastase datasheet

Clinical Indications

Primary Sclerosing Cholangitis
Crohn's disease
Ulcerative Colitis
Systemic Lupus Erythematosus
Elastase is implicated in congenital and cyclic neutropenia

MSDS

PDF-logo-dl  Material Safety Data Sheet

References

 

Baugh, R.J., Travis, J. (1976) Human leukocyte elastase: rapid isolation and characterization. Biochemistry 15, 836-41

Navia, M.A. et al. (1989) Structure if human neutrophil elastase in complex with peptide chloromethyl ketone inhibitor at 84-A resolution. Proc. Natl. Acad. Sci. USA 86, 7-11

Sato, T. et al. (2006) Neutrophil elastase and cancer. Surg. Oncol. 15, 217-22

Ho, A.-S. et al. (2014) Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers. Oncotarget 5, 473-80

Philip, A.G. et al. (1994) Neutrophil elastase in the diagnosis of neonatal infection.

Pediatr. Infect. Dis. J. 4, 323-6

Zorn, B. et al. (2003) Semen polymorphonuclear neutrophil elastase as a diagnostic and prognostic marker or genital tract inflammation - a review. Clin. Chem. Lab. Med. 41, 2-12

Langhorst, J. et al. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP and clinical indices. Am. J. Gastroenterol. 103, 162-9

Cohen Tervaert, J.W. et al. (1993) Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory bowel disorders. Ann. Rheum. Dis. 52, 115-20

Dale, D.C. et al. (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96, 2317-22