{"product_id":"ell-polyclonal-antibody-ra24515","title":"ELL Polyclonal Antibody - RA24515","description":"\u003cp\u003eELL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA24515-50, RA24515-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: disease:A chromosomal translocation involving ELL is found in acute leukemias. Translocation t (11;19) (q23;p13.1) with MLL\/HRX. The result is a rogue activator protein.,function:Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ELL\/occludin family.,subcellular location:Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.,subunit:Interacts with EAF1 and EAF2.,tissue specificity:Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: ELL; C19orf17; RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 8178\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 65\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P55199\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121255604403,"sku":"RA24515-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121255637171,"sku":"RA24515-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1332e377-56ab-41fb-919a-9c47582a7e0b.png?v=1773345761","url":"https:\/\/afsbio.com\/products\/ell-polyclonal-antibody-ra24515","provider":"AFSBio Inc.","version":"1.0","type":"link"}