{"product_id":"elp2-polyclonal-antibody-bs62368","title":"ELP2 Polyclonal Antibody-BS62368","description":"\u003cp\u003eELP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62368-50, BS62368-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q6IA86\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain. A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions. StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate. Because StIP1 can associate with several other members of the Stat family, it may serve a broad role in cytokine-signaling events.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ELP2 polyclonal antibody detects endogenous levels of ELP2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ELP2 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:L02 whole cell lysate\u003cbr\u003e\nLaneB:HEK293T whole cell lysate\u003cbr\u003e\nLaneC:A549 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 100 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Elongator complex protein 2; ELP2; SHINC-2; STAT3-interacting protein 1; StIP1; ELP2; STATIP1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human ELP2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910446158003,"sku":"BS62368-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910446190771,"sku":"BS62368-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_218ec52e-a16a-45f6-817d-88c49005f639.jpg?v=1703092544","url":"https:\/\/afsbio.com\/products\/elp2-polyclonal-antibody-bs62368","provider":"AFSBio Inc.","version":"1.0","type":"link"}