{"product_id":"emp2-polyclonal-antibody-e-ab-16404","title":"EMP2 Polyclonal Antibody - E-AB-16404","description":"\u003cp\u003eEMP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-16404-60, E-AB-16404-120, E-AB-16404-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: EMP2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: EMP 2; EMP-2; EMP2; EMP2; Epithelial membrane protein 2; Protein XMP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental biology, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P54851\u003c\/p\u003e\n\n\u003cp\u003eBackground: EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3\/PMP22 (growth arrest-specific-3\/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human EMP2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130626212019,"sku":"E-AB-16404-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130626244787,"sku":"E-AB-16404-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130626277555,"sku":"E-AB-16404-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_bbe7769e-05ad-4996-b058-865c195bba69.png?v=1709810332","url":"https:\/\/afsbio.com\/products\/emp2-polyclonal-antibody-e-ab-16404","provider":"AFSBio Inc.","version":"1.0","type":"link"}