{"product_id":"enos-monoclonal-antibody-mb65920","title":"eNOS Monoclonal Antibody - MB65920","description":"\u003cp\u003eeNOS Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB65920-50, MB65920-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Endothelial nitric-oxide synthase (eNOS) is an important enzyme in the cardiovascμlar system. It catalyzes the production of nitric oxide (NO), a key regμlator of blood pressure, vascμlar remodeling, and angiogenesis. The activity of eNOS is regμlated by phosphorylation at mμltiple sites. The two most thoroughly studied sites are the activation site Ser1177 and the inhibitory site Thr495. Several protein kinases including Akt\/PKB, PKA, and AMPK activate eNOS by phosphorylating Ser1177 in response to various stimμli. In contrast, bradykinin and H2O2 activate eNOS activity by promoting both Ser1177 phosphorylation and Thr495 dephosphorylation.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Nitric oxide synthase endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to human eNOS.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/2000), IHC (1\/200 - 1\/500)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of eNOS protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 133 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: AMPK Signaling Pathway, PI3K AKT signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P29474\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946392215731,"sku":"MB65920-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946392248499,"sku":"MB65920-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/enos-monoclonal-antibody-mb65920","provider":"AFSBio Inc.","version":"1.0","type":"link"}