{"product_id":"ep300-rabbit-pab-a13016","title":"EP300 Rabbit pAb - A13016","description":"\u003cp\u003eEP300 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A13016-20, A13016-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-P, IF\/ICC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 264kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: Refer to figures\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2033\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q09472\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: p300; KAT3B; MKHK2; RSTS2; EP300\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol,  preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: IHC-P, 1:50 - 1:200 IF\/ICC, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones, Transcription Factors, Nuclear Receptor Signaling, Cancer, Tumor suppressors, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Cell Cycle Control-G2 M DNA Damage Checkpoint, Endocrine Metabolism, Mitochondrial metabolism, Endocrine and metabolic diseases, Obesity, Immunology Inflammation, NF-kB Signaling Pathway, Neuroscience, Neurodegenerative Diseases, Stem Cells, Cardiovascular, Angiogenesis.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: EP300\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189543952563,"sku":"A13016-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189543985331,"sku":"A13016-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_b9bf308d-3a8e-4ff5-b27c-03df8a481c20.png?v=1766429474","url":"https:\/\/afsbio.com\/products\/ep300-rabbit-pab-a13016","provider":"AFSBio Inc.","version":"1.0","type":"link"}