{"product_id":"epha3-rabbit-polyclonal-antibody-es5125","title":"EphA3 Rabbit Polyclonal Antibody - ES5125","description":"\u003cp\u003eEphA3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5125-50, ES5125-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: EPHA3, ETK, ETK1, HEK, TYRO4, Ephrin type-A receptor 3, EPH-like kinase 4, EK4, hEK4, HEK, Human embryo kinase, Tyrosine-protein kinase TYRO4, Tyrosine-protein kinase receptor ETK1, Eph-like tyrosine kinase 1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from EphA3. at AA range: 540-620\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: EphA3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: EphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed, Highest level in placenta,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 100kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Axon guidance\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate\u003cbr\u003e\nDisease: Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM: 114500]\u003cbr\u003e\nFunction: Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 1 SAM (sterile alpha motif) domain\u003cbr\u003e\nSimilarity: Contains 2 fibronectin type-III domains\u003cbr\u003e\nTissue Specificity: Widely expressed. Highest level in placenta\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein, [Isoform 2]: Secreted\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: EPHA3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Ephrin type-A receptor 3\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P29319\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 29210\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: O08680\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313527869619,"sku":"ES5125-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313527902387,"sku":"ES5125-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/epha3-rabbit-polyclonal-antibody-es5125","provider":"AFSBio Inc.","version":"1.0","type":"link"}