{"product_id":"ephrin-b1-2-phospho-tyr330-rabbit-polyclonal-antibody-es1419","title":"Ephrin-B1\/2 (phospho Tyr330) Rabbit Polyclonal Antibody - ES1419","description":"\u003cp\u003eEphrin-B1\/2 (phospho Tyr330) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1419-50, ES1419-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: EFNB1, EFL3, EPLG2, LERK2, Ephrin-B1, EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2, EFNB2, EPLG5, HTKL, LERK5, Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human EFNB1\/2 around the phosphorylation site of Tyr330. AA range:284-333\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Ephrin-B1\/2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Ephrin-B1\/2 (Y330) Polyclonal Antibody detects endogenous levels of Ephrin-B1\/2 protein only when phosphorylated at Y330.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed (PubMed:8070404, PubMed:7973638), Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638), Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 59kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Axon guidance\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM: 304110], also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies\u003cbr\u003e\nFunction: Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons\/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons\u003cbr\u003e\nInduction: By TNF-alpha\u003cbr\u003e\nPTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain\u003cbr\u003e\nSimilarity: Belongs to the ephrin family\u003cbr\u003e\nSubunit: Interacts with GRIP1 and GRIP2\u003cbr\u003e\nTissue Specificity: Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Single-pass type I membrane protein Membrane raft May recruit GRIP1 and GRIP2 to membrane raft domains, [Ephrin-B1 C-terminal fragment]: Cell membrane, Single-pass type I membrane protein, [Ephrin-B1 intracellular domain]: Nucleus Colocalizes with ZHX2 in the nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: EFNB1\/EFNB2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Ephrin-B1\/Ephrin-B2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 13641\/13642\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P52796\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315126259891,"sku":"ES1419-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315126292659,"sku":"ES1419-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ephrin-b1-2-phospho-tyr330-rabbit-polyclonal-antibody-es1419","provider":"AFSBio Inc.","version":"1.0","type":"link"}