{"product_id":"epsin-1-rabbit-polyclonal-antibody-es2284","title":"Epsin 1 Rabbit Polyclonal Antibody - ES2284","description":"\u003cp\u003eEpsin 1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2284-50, ES2284-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: EPN1, Epsin-1, EH domain-binding mitotic phosphoprotein, EPS-15-interacting protein 1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from Epsin 1. at AA range: 140-220\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Epsin 1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Epsin 1 Polyclonal Antibody detects endogenous levels of Epsin 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Epithelium, Mammary gland,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 85kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Endocytosis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: The DPW repeat domain is involved in AP2A2 and clathrin binding\u003cbr\u003e\nDomain: The NPF repeat domain is involved in EPS15 binding\u003cbr\u003e\nFunction: Binds to membranes enriched in phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis\u003cbr\u003e\nOnline Information: The bubble's bend -Issue 42 of January 2004,PTM: Phosphorylated on serine and\/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation\u003cbr\u003e\nPTM: Ubiquitinated\u003cbr\u003e\nSimilarity: Belongs to the epsin family\u003cbr\u003e\nSimilarity: Contains 1 ENTH (epsin N-terminal homology) domain\u003cbr\u003e\nSimilarity: Contains 2 UIM (ubiquitin-interacting motif) repeats\u003cbr\u003e\nSubcellular Location: Associated with the cytoplasmic membrane\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cell membrane, Peripheral membrane protein Nucleus Membrane, clathrin-coated pit Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane Detected in presynaptic nerve terminals and in Golgi stacks May shuttle to the nucleus when associated with ZBTB16\/ZNF145 (By similarity)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: EPN1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Epsin-1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 13854\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q80VP1\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 117277\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: O88339\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314203349171,"sku":"ES2284-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314203381939,"sku":"ES2284-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/epsin-1-rabbit-polyclonal-antibody-es2284","provider":"AFSBio Inc.","version":"1.0","type":"link"}