{"product_id":"er81-polyclonal-antibody-ra24666","title":"ER81 Polyclonal Antibody - RA24666","description":"ER81 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA24666-50, RA24666-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: ETS variant 1 (ETV1) Homo sapiens This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alte\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/10000. Not yet tested in other applications.\n\nAlternative Names: ETV1; ER81; ETS translocation variant 1; Ets-related protein 81\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse\n\nGeneID (Human): 2115\n\nProtein MW (KDa): 60\n\nSWISS: P50549\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121263698099,"sku":"RA24666-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121263730867,"sku":"RA24666-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_bca9234a-b7b1-425e-bb19-e86c97c1d62b.png?v=1773345839","url":"https:\/\/afsbio.com\/products\/er81-polyclonal-antibody-ra24666","provider":"AFSBio Inc.","version":"1.0","type":"link"}